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Her investigations provide some new clues about how phytochemicals attack cancer cells. For example, she found that the phytochemicals interfere with the orderly operations of mitochondria, the miniature energy-producing power plants inside cells. Without energy, cells die.

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Mitochondria exposed to resveratrol and the other phytochemicals that Zunino tested couldn't function properly. But more work is needed, to fully understand how the phytochemicals achieved that. And, Zunino and colleagues want to know more about the phytochemicals' other modes of action that result in cell death.

She's collaborating in the investigations with molecular biologist David Storms at WHNRC; Jonathan Ducore at the University of California-Davis Cancer Center; and Navindra Seeram, formerly with the University of California-Los Angeles and now at the University of Rhode Island-Kingston.

Read more about the research in the March 2008 issue of Agricultural Research magazine. ARS is the U.S. Department of Agriculture's chief scientific research agency.

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